MOTS-c
What does "Mitochondrial-Derived Peptide" mean?
MOTS-c is unique because it's encoded in the mitochondrial DNA, not the nuclear DNA where most genes live. It's studied as a potential "exercise mimetic."
Explained Simply
When you exercise, your muscles send signals to the rest of your body that help you stay healthy. MOTS-c is like one of those exercise signals.
How It Works
MOTS-c works by activating AMPK, often called the "master metabolic switch." This activation triggers a cascade that improves how cells use glucose and fat for energy.
Research by Sex
Effects in Men
- •Research shows exercise-induced MOTS-c increases in male subjects
- •Studies indicate metabolic benefits consistent with female findings
- •Skeletal muscle function research includes male populations
Effects in Women
- •MOTS-c response to exercise observed in female subjects
- •Metabolic regulation benefits appear consistent
- •Research on insulin sensitivity shows similar outcomes
Key Terms Explained
Mitochondrial DNA
The small genome inside mitochondria, separate from nuclear DNA
AMPK
AMP-activated protein kinase, a key regulator of energy metabolism
Research Areas
- •Metabolic regulation and insulin sensitivity
- •Exercise mimetic effects
- •Mitochondrial function and biogenesis
- •Longevity and aging research
Published Studies
Laboratory Protocols
Storage
Store lyophilized peptide at -20°C.
Reconstitution
Reconstitute in sterile water or bacteriostatic water.
Quick Facts
Category
Mitochondrial-Derived Peptide
Molecular Weight
1756.98 g/mol
Half-Life
~4-6 hours
Amino Acid Sequence
Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
Grokipedia
Quick Reference
View detailed research data including key facts, mechanism of action, and safety profile.
Disclaimer: This information is provided for educational purposes only. These products are intended for laboratory research use only. Not for human consumption.
Grokipedia
Quick Reference
MOTS-c
MOTS-c is a 16-amino acid peptide encoded within the 12S rRNA gene of mitochondrial DNA. It represents a novel class of mitochondrial-derived peptides and is studied as a potential exercise mimetic.
Key Facts
- •16-amino acid peptide
- •Molecular weight: 1756.98 g/mol
- •Mitochondrial DNA encoded
- •AMPK pathway activator
- •Exercise-induced release
Mechanism of Action
Activates AMPK, the master metabolic switch. Improves glucose uptake and fatty acid oxidation. Levels increase with exercise and decline with age. May provide exercise-like metabolic benefits.
Research Applications
- Metabolic regulation research
- Exercise mimetic studies
- Insulin sensitivity research
- Aging and longevity studies
Safety Profile
Endogenous mitochondrial peptide. Limited human data. Animal studies show metabolic benefits. Research use only.
Disclaimer: This information is for educational and research purposes only. Products are intended for laboratory research use only. Not for human consumption.