PT-141 (Bremelanotide)
What does "Melanocortin Receptor Agonist" mean?
Melanocortins are a family of hormones that affect many systems including skin pigmentation, appetite, and behavior. PT-141 activates several of these receptors.
Explained Simply
Your brain has special switches that control many things including mood, appetite, and attraction. PT-141 works on one of these switches called the melanocortin system.
How It Works
PT-141 activates melanocortin receptors in the brain, particularly MC4R. This is fundamentally different from compounds that work through blood vessel dilation.
Research by Sex
Effects in Men
- •Research shows effects through central nervous system pathways
- •Studies indicate mechanism is distinct from vascular approaches
- •Brain-based action rather than blood flow modification
Effects in Women
- •FDA-approved for hypoactive sexual desire disorder in premenopausal women
- •Research shows effects on desire through central mechanisms
- •Studies document improvements in arousal and satisfaction measures
Key Terms Explained
Melanocortin
A family of hormones that affect pigmentation, appetite, and behavior
MC4R
Melanocortin 4 receptor, found in the brain, affecting appetite and behavior
Research Areas
- •Melanocortin receptor signaling
- •Central nervous system effects on behavior
- •Appetite and feeding behavior
- •Stress and anxiety responses
Published Studies
Laboratory Protocols
Storage
Store lyophilized peptide at -20°C protected from light.
Reconstitution
Reconstitute with bacteriostatic water. Use within 30 days of reconstitution.
Quick Facts
Category
Melanocortin Receptor Agonist
Molecular Weight
1025.21 g/mol
Half-Life
~2-3 hours
Amino Acid Sequence
Ac-Nle-cyclo(Asp-His-D-Phe-Arg-Trp-Lys)-OH
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Grokipedia
Quick Reference
PT-141 (Bremelanotide)
PT-141 is a cyclic heptapeptide and synthetic analog of alpha-melanocyte-stimulating hormone. It acts through central nervous system melanocortin receptors rather than peripheral vascular mechanisms.
Key Facts
- •Cyclic heptapeptide structure
- •Molecular weight: 1025.21 g/mol
- •Half-life: 2-3 hours
- •MC4R receptor agonist
- •CNS-mediated mechanism
Mechanism of Action
Activates melanocortin receptors in the brain, particularly MC4R. Works through central nervous system pathways rather than blood vessel dilation. Affects appetite, stress responses, and behavior through melanocortin signaling.
Research Applications
- Melanocortin receptor research
- CNS behavioral studies
- Appetite regulation research
- Stress response studies
Safety Profile
FDA-approved for specific indication in premenopausal women. May cause nausea, flushing. Blood pressure monitoring recommended. Research use requires appropriate protocols.
Disclaimer: This information is for educational and research purposes only. Products are intended for laboratory research use only. Not for human consumption.