Sermorelin
What does "Growth Hormone Releasing Hormone (GHRH) Analog" mean?
Sermorelin is a shortened version of natural GHRH, containing only the first 29 amino acids. This truncated form retains full biological activity for stimulating growth hormone release.
Explained Simply
Natural GHRH is 44 amino acids long, but researchers found that only the first 29 are needed to work. Sermorelin is that shortened version - it tells your body to make more growth hormone naturally.
How It Works
Sermorelin binds to GHRH receptors on anterior pituitary somatotrophs, stimulating the synthesis and release of endogenous growth hormone. It maintains the natural pulsatile GH secretion pattern and is regulated by somatostatin feedback.
Research by Sex
Effects in Men
- •Research shows increased GH secretion in GH-deficient men
- •Studies indicate improvements in body composition parameters
- •Potential benefits for age-related GH decline
Effects in Women
- •Efficacy demonstrated in female subjects with GH deficiency
- •Research shows comparable GH responses to men
- •Studies include post-menopausal women with positive outcomes
Key Terms Explained
GRF 1-29
Growth hormone releasing factor, amino acids 1-29
Somatostatin
A hormone that inhibits growth hormone release, providing negative feedback
Pulsatile secretion
Release of hormones in rhythmic bursts rather than continuously
Research Areas
- •Growth hormone deficiency treatment
- •Age-related GH decline
- •Body composition and metabolism
- •Sleep quality research
- •Pediatric growth disorders
Published Studies
Laboratory Protocols
Storage
Store lyophilized peptide at 2-8°C or -20°C for long-term storage.
Reconstitution
Reconstitute with bacteriostatic water. Store reconstituted solution at 2-8°C.
Quick Facts
Category
Growth Hormone Releasing Hormone (GHRH) Analog
Molecular Weight
3357.9 g/mol
Half-Life
~10-20 minutes
Amino Acid Sequence
Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2
Disclaimer: This information is provided for educational purposes only. These products are intended for laboratory research use only. Not for human consumption.