TB500 Frag 17-23
What does "Healing/Recovery Fragment" mean?
This is a smaller piece (fragment) of the larger TB-500 molecule, specifically amino acids 17-23. Researchers study fragments to understand which parts of a protein are responsible for specific effects.
Explained Simply
Imagine a key that opens many locks. Sometimes scientists want to make a smaller key that only opens one specific lock. TB500 Frag 17-23 is like that smaller key - it may do specific things the full molecule does, but in a more targeted way.
How It Works
The fragment 17-23 contains key residues for actin interaction. Research investigates whether this minimal sequence retains the tissue repair properties of the full peptide.
Research by Sex
Effects in Men
- •Fragment research is ongoing with limited sex-specific data
- •Studies focus on mechanism rather than clinical outcomes
- •Preliminary research conducted in mixed populations
Effects in Women
- •Similar to men, fragment research is in early stages
- •No significant sex-based differences reported in studies
- •Research primarily focuses on molecular mechanisms
Key Terms Explained
Fragment
A smaller piece of a larger protein, containing a specific active region
Heptapeptide
A peptide consisting of exactly seven amino acids
Research Areas
- •Minimal active sequence identification
- •Actin-binding domain function
- •Targeted tissue repair applications
- •Structure-activity relationships
Published Studies
Laboratory Protocols
Storage
Store lyophilized peptide at -20°C protected from light and moisture.
Reconstitution
Reconstitute with bacteriostatic water. Use small volumes for accurate concentration.
Quick Facts
Category
Healing/Recovery Fragment
Molecular Weight
~750 g/mol
Half-Life
~1-2 hours
Amino Acid Sequence
Leu-Lys-Lys-Thr-Glu-Thr-Gln
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Quick Reference
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Grokipedia
Quick Reference
TB-500 (Thymosin Beta-4)
TB-500 is a synthetic version of the active region of Thymosin Beta-4, a 43-amino acid peptide found in almost all human and animal cells. It regulates actin, a protein essential for cell structure and movement.
Key Facts
- •43-amino acid peptide
- •Molecular weight: 4963.44 g/mol
- •Half-life: 2-4 hours
- •Actin-sequestering protein
- •Found in nearly all cell types
Mechanism of Action
Sequesters G-actin monomers, regulating actin polymerization critical for cell motility. Controls how cells move, divide, and heal. Influences wound healing, cardiac tissue repair, and inflammatory responses.
Research Applications
- Wound healing and tissue repair
- Cardiac regeneration research
- Hair follicle studies
- Anti-inflammatory research
Safety Profile
Research compound. Well-characterized mechanism. Animal studies show tissue repair benefits. Human clinical data limited. Research use only.
Disclaimer: This information is for educational and research purposes only. Products are intended for laboratory research use only. Not for human consumption.