Tesamorelin
What does "Growth Hormone Releasing Hormone (GHRH) Analog" mean?
GHRH is a hormone your brain releases to tell your pituitary gland to produce growth hormone. Tesamorelin is a modified version of this natural hormone that lasts longer in the body.
Explained Simply
Your brain has a "release growth hormone" button that it normally pushes on its own. Tesamorelin is like pushing that button more consistently, helping your body make growth hormone the natural way.
How It Works
Tesamorelin binds to GHRH receptors on pituitary somatotroph cells, triggering the natural release of growth hormone. Unlike exogenous GH, it preserves the physiological pulsatile pattern of GH secretion.
Research by Sex
Effects in Men
- •FDA-approved for HIV-associated lipodystrophy in adults
- •Research shows reduction in visceral adipose tissue
- •Studies indicate improved body composition without testosterone interference
Effects in Women
- •Efficacy demonstrated in female subjects with lipodystrophy
- •Research shows comparable visceral fat reduction
- •Studies on metabolic parameters include female populations
Key Terms Explained
GHRH
Growth Hormone Releasing Hormone, a signal that tells the pituitary to produce growth hormone
Somatotrophs
Cells in the pituitary gland that produce growth hormone
Lipodystrophy
Abnormal fat distribution, often involving excess fat in the abdomen
Research Areas
- •Lipodystrophy treatment
- •Visceral adipose tissue reduction
- •Metabolic syndrome research
- •Age-related GH decline
- •Body composition optimization
Published Studies
Laboratory Protocols
Storage
Store lyophilized peptide at 2-8°C. Protect from light.
Reconstitution
Reconstitute with sterile water for injection. Use immediately or store at 2-8°C for up to 14 days.
Quick Facts
Category
Growth Hormone Releasing Hormone (GHRH) Analog
Molecular Weight
5135.9 g/mol
Half-Life
~26-38 minutes
Amino Acid Sequence
Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH2 (trans-3-hexenoic acid attached)
Disclaimer: This information is provided for educational purposes only. These products are intended for laboratory research use only. Not for human consumption.